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Products

AMITIZA WITHIN THE UNITED STATES

To learn more about AMITIZA and constipation, please visit:

http://www.amitiza.com/
http://www.letstalkconstipation.com/

Click here for full U.S. Prescribing Information for AMITIZA

For more information or to report suspected adverse reactions related to AMITIZA, please call toll-free at 1-877-825-3327.  Alternatively, you can report suspected adverse reactions directly to the FDA at www.FDA.gov/medwatch or call 1-800-FDA-1088.

RESCULA WITHIN THE UNITED STATES

To learn more about RESCULA, please visit:

www.rescula.com/

Click here for full U.S. Prescribing Information for RESCULA

For more information or to report suspected adverse reactions related to RESCULA, please call toll-free at 1-855-RESCULA (1-855-737-2852).  Alternatively, you can report suspected adverse reactions directly to the FDA at www.FDA.gov/medwatch or call 1-800-FDA-1088.

 

The table below summarizes the development status of lubiprostone, unoprostone isopropyl and several other prostone-based product candidates. We currently hold the commercialization rights to the prostone compounds in our product pipeline, other than for commercialization of AMITIZA in the U.S., Canada and Japan, which is covered by our collaboration and license agreements with Takeda Pharmaceutical Company, Limited and Abbott Japan Co., Ltd. and for RESCULA, for which we hold certain rights except in the R-Tech Territory (Japan, Korea, Taiwan and the People’s Republic of China).

Clinical Focus

Lead Compound

Stage of Clinical Development

  • Discovery

  • Pre-Clinical

  • Phase 1

  • Phase 2

  • Phase 3

lubiprostone

  • Liquid Formulation CIC 1
  • Pediatric Constipation 2
  • Began 3Q13
  • Phase 3, FPFV 4Q13*

unoprostone isopropyl

  • Retinitis Pigmentosa**
  • Began 1Q13

cobiprostone

  • Oral Mucositis
  • Phase 1b, Began 4Q13

IV Ion Channel Activator

  • Spinal Stenosis
  • Phase 2a, Began 1Q13

PO Ion Channel Activator

  • Spinal Stenosis
  • Phase 1b, 1Q14*

1 Chronic Idiopathic Constipation 2 Pediatric Functional Constipation * Projected Start or Submission **Co-developing with R-Tech Ueno, Ltd.