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Science & Innovation

 

Sucampo’s commitment to science and pharmaceutical innovation has yielded a robust pipeline across many research areas, with upcoming clinical milestones.

 
 

Pipeline

We are working to accelerate the development of additional formulations of lubiprostone, while at the same time developing therapies that have the potential to treat a variety of other diseases or conditions, with a focus on therapeutic areas where significant unmet or underserved needs exist.

 

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Clinical Focus

Stage of Clinical Development Completed

Lead Compounds

Pre-Clinical

Phase 1

Phase 2

Phase 3

Lubiprostone - Pediatric Functional Constipation (6 years - 17 years)

Lubiprostone for pediatric functional constipation is being investigated for children 6 years to 17 years of age. Constipation is one of the most common gastrointestinal complaints in children. Constipation in children has similar characteristics to that of constipation in adults in that symptoms include infrequent bowel movements, hard stools, large diameter stools and painful passage of stools.

For more about our clinical trials in this area, please visit:

https://clinicaltrials.gov/ct2/show/NCT02042183

https://clinicaltrials.gov/ct2/show/NCT02138136

Lubiprostone - Alternate Formulation

An alternate formulation of lubiprostone is being investigated for additional adult and pediatric patients who cannot tolerate capsules or naso-gastric, tube fed patients. This alternate formulation will be used in the pediatric functional constipation program for children 6 months to 6 years in age. Constipation is characterized by the infrequent or difficult passage of stool. Chronic constipation is idiopathic (of unknown or spontaneous origin) if it is not caused by other diseases or by use of medications.

Lubiprostone - Pediatric Functional Constipation (6 months - 6 years)

Lubiprostone for pediatric functional constipation is being investigated for children 6 months to 6 years of age. This program will use the alternate formulation. Constipation is one of the most common gastrointestinal complaints in children. Constipation in children has similar characteristics to that of constipation in adults in that symptoms include infrequent bowel movements, hard stools, large diameter stools and painful passage of stools.

CPP-1X/sulindac Combination Product

Sucampo entered into an exclusive option and collaboration agreement with Cancer Prevention Pharmaceuticals (CPP) in January 2016. Sucampo was granted the sole option to acquire an exclusive license to commercialize CPP-1X/sulindac combination in North America. This product is currently in a phase 3 clinical trial for the treatment of familial adenomatous polyposis (FAP). A genetic disease, FAP typically develops into colon cancer if left untreated. FAP has been designated an orphan indication in the U.S. and Europe, with a prevalence of about 1 in 10,000, and approximately 30,000 cases in the U.S. There are currently no approved treatments for FAP and no other products in late-stage development.

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Tel: +1-301-961-3400